Pillars Article: Approaching the Asymptote? Evolution and Revolution in Immunology. Cold Spring Harb Symp Quant Biol. 1– Author: Janeway CA Jr, Journal: Cold Spring Harbor symposia on quantitative biology[]. Author: Janeway CA Jr, Journal: Journal of immunology (Baltimore, Md.: )[ /11] Evolution and revolution in immunology. Cold spring harb symp.

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The New England Journal of Medicine. Regulatory responses in contact sensitivity: Science New York, N.

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Latest Complete Volume Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide Proceedings of the National Academy of Sciences of the United States of America. On the complexity of self Nature.

Stimulator cell type influences the response of T cells to staphylococcal enterotoxins Journal of Immunology. It continues to surprise me that something that I should know, without question, can still surprise me when expressed in a slightly different way the early perception of a serum-antibody-centric immune universe.

I reckon that this change from a lympho-centric to an inflammo-centric system is pretty much comparable to a Copernican shift. Dual receptor T cells extend the immune repertoire for foreign antigens.

Jerne actually shared the Nobel Prize in Physiology or Medicine specifically for this theory; unofficially, he won it for his theoretical genius and a immunilogy of scientific contributions. Phylogenetic perspectives in innate immunity.


On the intrathymic intercellular transfer of self-determinants Immunology Today. How does the immune system distinguish self from nonself? It marked the acceptance of the clonal selection theory as the central paradigm of immunology Jerne A role for self-peptides in positive selection Current Biology.

Approaching the Asymptote? Evolution and Revolution in Immunology

Current Opinion in Immunology. The last issue Journal of Molecular and Cellular Immunology. An ancient system of host defense.

Antibodies have a bit more leeway but, in vivo, not as much as you may anticipate. Its influential shadow looms as large for immunology research today as it did in the s. Insulin-dependent diabetes mellitus and its animal models Current Opinion in Immunology. Makes a little sense Nature.

Revolutions in Immunology | IMMpress Magazine

Latest posts by Michael Le see all. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice Journal of Experimental Medicine. Humoral immunity at the turn of the 20th century was as fashionable as the microbiome is today. One could consider the early days of immunology as little more than curious diversions from the more established research disciplines.

If not, is there a Burnet, Jerne, or Janeway of this generation that has the ingenuity and more importantly, the guts, to point us in a new direction? Michael is a 4th year PhD student in the Department of Immunology at the University of Toronto studying how B cells diversify their antibodies to fight infections. Can the existing framework of immunology provide the answer to these questions and more?


Charles Janeway – Publications Affiliations: His prediction formed the basis for a new field of innate immunity that was based on recognition of non-clonal patterns found on pathogens.

Revolutions in Immunology

June 15, at 1: Excellent historical and present day synopsis of the scientific pursuit and of the field of immunology. This extract was created in the absence immunoloty an abstract.

The co-receptor function of CD4 Seminars in Immunology. But how appropriate is the definition to the more youthful, multidisciplinary field of immunology? To thine own self be true. Yet history has taught us that even the most widely respected scientific theories have limited lifespans; they become outmoded as new, more attractive ideas take their place.

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis Science. The short answer was the clonal selection theory.