For Injection: Teflaro is supplied as mg or mg of sterile ceftaroline fosamil powder in single-dose, 20 mL clear glass. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal . To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should be used to.
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The kidney was cfftaroline primary target organ of toxicity in both the monkey and rat. Infusion time minutes c. Refers to dosing of adults or adolescents from 12 years and 33 kg with ceftaroline every 8 hours using 2-hour infusions to treat cSSTI see section 4.
To email a medicine you must sign up and log ceftariline. There is minimal potential cefgaroline drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal secretion; and drugs that may alter renal blood flow. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of ceftaroline fosamil see section 4.
However, the frequency of rash in the subgroup of Asian patients receiving Zinforo every 8 hours was very common Infect Dis Clin Pract. From a microbiological point of view, the medicinal product should be used immediately.
Please also see full Prescribing Information. If you are a patient, and have any questions, please discuss them with your doctor or healthcare professional.
No dosage adjustment is considered necessary in patients with hepatic impairment see section 5. I prefer to be contacted by: Fertility The effects of ceftaroline fosamil on fertility on humans have not been studied. Marketing authorisation holder 8.
TEFLARO® (ceftaroline fosamil) Dosing Information
The pharmacokinetics of ceftaroline in patients with hepatic impairment has not been established. Patients with pre-existing seizure disorder Seizures have occurred in toxicology studies at times human ceftaroline C max levels see section 5. Renal clearance of ceftaroline is approximately equal, or slightly lower than the glomerular filtration rate in the kidney, and in vitro transporter studies indicate that active secretion does not contribute to the renal elimination of ceftaroline.
Complains of fever, cough with pleuritic chest pain, sputum production, occasional blood streaks in ceftarlline within the past couple of days. As ceftaroline does not appear to undergo significant hepatic metabolism, the systemic clearance of ceftaroline is not expected to be significantly affected by hepatic impairment. Infect Dis Clin Pract. Store in the original package in order to protect from light.
Preferred Contact is required Phone. Hepatic impairment The pharmacokinetics of ceftaroline in patients with hepatic impairment has not been established. Date of revision of the text. Refers to dosing of adults or adolescents from 12 years and 33 kg with ceftaroline every 12 hours using 1-hour infusions see section 4.
CrCL should be closely monitored and the dose adjusted according to changing renal function. Table 5 Frequency of adverse reactions by system organ class from clinical trials and post-marketing experience System organ class Very common Common Uncommon Rare Not known Infections and infestations Clostridium difficile colitis see section 4.
Please also see full Prescribing Information. Reasons for being admitted to the hospital through the emergency department, This site is intended for U.
When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. Patients who have a history of hypersensitivity to cephalosporins, penicillins or other beta-lactam antibacterials may also pqckage hypersensitive to ceftaroline fosamil. After reconstitution, 1 ml of the solution contains 30 mg of ceftaroline fosamil.
Zinforo 600 mg powder for concentrate for solution for infusion
Histopathologic findings included pigment deposition and inflammation of the tubular epithelium. Susceptibility data should be considered in conjunction with clinical trial data also presented on this website.
The reconstituted vial should be diluted immediately. Genetic toxicology Ceftaroline fosamil and ceftaroline were clastogenic in an in vitro chromosomal aberration assay, however there was no evidence of mutagenic activity in an Ames test, mouse lymphoma and unscheduled Insdrt synthesis assay.