This resource may include information that has not been approved by the US Food and Drug Administration. For full prescribing information, including. Fosphenytoin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Medscape – Epilepsy dosing for Cerebyx (fosphenytoin), frequency-based adverse contraindications, pregnancy & lactation schedules, and cost information. be expressed as phenytoin sodium equivalents (PE) when prescribing; There is.
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Epanolol The metabolism of Epanolol can be increased when combined with Fosphenytoin. As a general principle, monotherapy is preferred for treating prescrlbing in pregnancy whenever possible because therapy with multiple AEDs could be associated with a higher risk of congenital malformations than monotherapy, depending on the associated AEDs.
HIGHLIGHTS OF PRESCRIBING INFORMATION
Drug a Mechanism Antineoplastic agents e. Ibipinabant The risk or severity of adverse effects can be increased when Ibipinabant is combined with Fosphenytoin. The mechanism of fosphenytoin conversion has not been determined, but phosphatases probably play a major role.
Although a cause and effect relationship has not been established, the occurrence of lymphadenopathy indicates the need to differentiate such a condition from other types of lymph node pathology. Fosphenytoin sodium Dosage Form: Metyrosine Fosphenytoin may increase the sedative activities of Metyrosine. Isavuconazole The metabolism of Isavuconazole can be increased when combined with Fosphenytoin. Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Fsphenytoin.
Gestrinone The metabolism of Fosphenytoin can be decreased when combined with Gestrinone.
Phenytoin Pharmacokinetics after Pro-Epanutin administration: Dose mg phenytoin sodium. When appropriate, counsel pregnant women and women of childbearing potential about alternative therapeutic options. In order to obtain rapid seizure control in patients with continuous seizure activity IV diazepam or lorazepam should be administered prior to administration prescribin Pro-Epanutin. This may or may not be associated with extravasation. Even though loading doses of Fosphenytoin Sodium Injection have been given by the IM route for other indications when IV access is impossible, IM Fosphenytoin Sodium Injection should ordinarily not be used in the treatment of status epilepticus because therapeutic phenytoin concentrations may not be reached as quickly as with IV administration.
After dilution Pro-Epanutin is suitable only for immediate use.
FOSPHENYTOIN SODIUM Injection mg PE in 2ml Vial mg PE in 10 ml Vial | Mylan
The addition or withdrawal of phenytoin during concomitant therapy with these agents may require adjustment of the dose of these agents to achieve optimal clinical outcome. Signs of formate toxicity are similar to those of methanol toxicity and are associated with severe anion-gap metabolic acidosis. Avasimibe The metabolism of Fosphenytoin can be increased when combined with Avasimibe.
Lortalamine The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Lortalamine.
Whether or not phenytoin has the same effect on other non-depolarizing agents is unknown. Maintenance doses should be adjusted according to patient response and trough plasma phenytoin concentrations see Therapeutic Drug Monitoring. To view the changes to a medicine you must sign up and log in. Formaldehyde is subsequently converted to formate, which is in turn metabolised via a folate dependent mechanism.
The extent of conversion to phenytoin is not affected. fophenytoin
Fosphenytoin – FDA prescribing information, side effects and uses
Amphetamine The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Amphetamine. Diphenoxylate Prescribiing risk or severity of adverse effects can be increased when Diphenoxylate is combined with Fosphenytoin. Therefore patients should be monitored for signs of suicidal ideation and behaviours and appropriate treatment should be considered.
Bromotheophylline The serum concentration of Bromotheophylline can be decreased when it is combined with Fosphenytoin.
The rate of conversion of IV Pro-Epanutin to phenytoin may be increased in these patients. Intramuscular IM administration of Pro-Epanutin is not recommended in the treatment of status epilepticus. Alfaxalone The informaation or severity of adverse effects can be increased when Fosphenytoin is combined with Alfaxalone.
Fertility In animal studies, fosphenytoin had no effect on fertility in male rats but decreased fertility in female rats see section 5. Hydrocortisone The metabolism of Fosphenytoin can be increased when combined with Hydrocortisone.
Reduction in rate of administration or discontinuation of dosing may be needed. Prenatal exposure to phenytoin the active metabolite of Fosphenytoin Sodium Injection may increase the risks for congenital malformations and other adverse developmental outcomes [see Use in Specific Populations fowphenytoin.
Azelnidipine The metabolism of Fosphenytoin can be decreased when combined with Azelnidipine. Cyclopropane The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Cyclopropane.
Because of the risks of cardiac and local toxicity associated with intravenous Fosphenytoin Sodium Injection, oral phenytoin should be used whenever possible. Table 9 displays dosing information for seizure treatment or prophylaxis maintenance dose in children. Following administration of oral phenytoin, phenytoin appears to be excreted in low concentrations in human milk.
Levocetirizine The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Levocetirizine.
Lopinavir The serum concentration of Lopinavir can be decreased when it is combined with Fosphenytoin. Metyrapone The serum concentration of Metyrapone can be decreased when it is combined with Fosphenytoin.