ABSTRACT. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and. Abstract: Inositol hexaphosphate (IP6) is a naturally occur- ring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain. While IP-6 is found in rice bran and other foods, there are good reasons to take an IP-6 & Inositol supplement. First, IP-6 is getter absorbed in pure form without.

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It was recently recognized to possess multiple biological functions.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Apoptosis is a hallmark of action of many anticancer drugs. Tumors depend on the formation of new blood vessels to support their growth and metastasis. A pilot clinical trial. The effectiveness of IP 6 as a cancer preventive agent was shown in colon cancer induced in different species rats and mice with different carcinogens 12 -dimethylhydrazine and azoxymethane 18 — 2040 — IP 6 may serve as a natural antioxidant 11 and possibly as a neurotransmitter In addition to reducing cell proliferation, IP6 increases differentiation of malignant cells, often resulting in a reversion to normal phenotype.

Comparative toxicities of selected minor dietary non-nutrients with chemopreventive properties. Exogenously administered IP 6 is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. A single treatment of HepG2 cells in vitro by IP 6 resulted in the complete loss of the ability of these cells to form tumors when inoculated subcutaneously in nude mice Receive exclusive offers and updates from Oxford Academic.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Inositol hexaphosphate inhibits large intestinal cancer in F rats 5 months after induction by azoxymethane. Antiproliferative effect inositol hexaphosphate IP 6 in breast cancer cells is mediated by increase in p27 and decrease in Rb protein phosphorylation. Using a novel and highly sensitive method combining gas chromatography—mass spectrometry analysis and HPLC, Grases et al.

Effects of dietary myo-inositol or phytic acid on hepatic concentrations of lipids and hepatic activities of lipogenic enzymes in rats fed on corn starch or sucrose.


However, the effectiveness and safety of IP6 plus inositol at therapeutic doses needs to be determined in phase I and phase II clinical trials in humans. Lowering of serum cholesterol and triglycerides and modulations by dietary phytate. IP 6 induces G 1 phase arrest and a significant decrease of the S phase of human breast 6869colon 69and prostate 34 cancer cell lines. That the extracellularly applied IP 6 enters the cell and that this intracellular delivery is followed by a dephosphorylation of IP 6 was recently confirmed by Ferry et al.

Suppression of large intestinal cancer in F rats by inositol hexaphosphate. It was recently recognized to possess multiple biological functions. Furthermore, IP 6 reduced O -tetradecanoylphorbolacetate—induced ornithine decarboxylase activity, an essential event in tumor promotion in HEL cells, a murine keratinocyte cell line Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU Modulatory influence of arecoline on the phytic acid-altered hepatic biotransformation system enzymes, sulfhydryl content and lipid peroxidation in a murine system.

However, IP 6 causes the accumulation of human leukemia cells in the G 2 M phase of the cell cycle; a cDNA microarray analysis showed a down-modulation of multiple genes involved in transcription and cell-cycle regulation by IP 6 IP 6 inhibited the growth and differentiation of endothelial cells 6672 and inhibited the secretion of vascular endothelial growth factor from malignant cells 2766 IP 6 decreased the incidence of aberrant crypts when they were used as an intermediate biomarker for colon cancer 43 IP 6 was administered orally either as the pure sodium salt or in a diet to reduce hypercalciuria and to prevent formation of kidney stones, and no evidence of toxicity was reported 646579 Effect of inositol hexaphosphate on growth and differentiation in K erythroleukemia cell line.

All these proposed hypotheses have been confirmed. IP 6a natural compound with virtually no toxicity, can satisfy this special and very important requirement for cancer prevention. Inositol hexaphosphate InsP 6: Its induction of terminal differentiation 262829323338restoration of immune response 59modulation of growth factors 58modulation of signal transduction pathways 15163557induction of apoptosis 253445and possibly inhibition of oncogene activity and restoration of tumor suppressor function are well documented.

Studies using other experimental models showed that antineoplastic properties of IP 6 were not restricted to the colon. Inositol hexaphosphate IP 6 inosiotl a naturally occurring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain high-fiber diets, such as cereals and legumes.


Inhibition of mammary carcinogenesis by inositol hexaphosphate phytic acid. We found that inositol alone or in combination with IP 6 can prevent the formation and incidence of several cancers in experimental animals: Besides affecting tumor cells, IP 6 can act on a host by restoring its immune system. It was also hypothesized inosutol the addition of inositol, a precursor of inositol phosphates and also a natural carbohydrate, to IP 6 may enhance the anticancer function of Inozitol 6 18 — Additionally, we showed that inositol potentiates both the antiproliferative and antineoplastic effects of IP 6 in vivo 3 — 51939 inosifol, 51 A long-term intake of IP 6 in food 6061 or in a pure form 64 did not cause such a deficiency in humans.

Protection against cancer by dietary IP6 and inositol.

IP 6 is a natural compound and an important dietary component. IP 6 was further shown to increase differentiation of human colon carcinoma HT cells 2829prostate cancer cells 33 inosutol, breast cancer cells 32and rhabdomyosarcoma cells As hypothesized, it was demonstrated that IP 6 is a broad-spectrum antineoplastic agent, affecting different cells and tissue systems.

A novel anticancer function of inositol hexaphosphate IP 6 ; 4 also Ins P 6 and phytic acid has been shown both in vivo and in vitro 3 — 5. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Impairment of erbB1 receptor and fluid phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU cells.

The role of IP 6 among these multiple signaling pathways and their cross-talk in regulation of cell functions needs to be addressed in the future. Antitumor activity of phytic acid inositol hexaphosphate in murine transplanted and metastatic fibrosarcoma, a pilot study.

IP 6 also inhibited the growth of mesenchymal tumors, murine fibrosarcoma 39and human rhabdomyosarcoma Studies in human mineral metabolism. Inhibition of skin cancer by IP 6 in vivo: